Exploring NMR ensembles of calcium binding proteins: Perspectives to design inhibitors of protein-protein interactions.
Protein-protein interactions (PPIs) are important for regulating many biological functions. It has been suggested that the human interactome involves about 650,000 interactions and disrupting these interactions could be an attractive way to block a number of targets involved in different pathologies. A possible strategy to inhibit undesired PPIs is
Binary classification of protein molecules into intrinsically disordered and ordered segments.
Understanding of human proteins is doubtlessly essential for both basic and applied sciences. With protein structures accumulating and protein structure prediction improving, it is becoming increasingly accurate to assign structural domains (SDs) to amino acid sequences. Although structural domains in proteins (SDs) are important,
Faulty Molecular Switch Can Cause Infertility or Miscarriage
Scientists have discovered an enzyme that acts as a 'fertility switch', in a study published in Nature Medicine on October 16.
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